Comparison of Predictive<i> In Silico</i> Tools on Missense Variants in<i> GJB2</i>,<i> GJB6</i>, and<i> GJB3</i> Genes Associated with Autosomal Recessive Deafness 1A (DFNB1A)

<div>Localization of the tested nonsynonymous (missense) amino acid substitutions in the structure of connexin 26.<i> Note.</i> The information about the structure Сx26 was obtained from the database of three-dimensional structures of proteins and nucleic acids PDB ID:2ZW3 (<a href="https://www.ncbi.nlm.nih.gov/Structure/pdb/2ZW3">https://www.ncbi.nlm.nih.gov/Structure/pdb/2ZW3</a>) [<a href="/journals/tswj/2019/5198931/#B45">22</a>]. Localization of the studied amino acids in structure of Cx26 was obtained using the 3D-structure viewer applet with the protein structure loaded software PolyPhen-2 (<a href="http://genetics.bwh.harvard.edu/pph2/">http://genetics.bwh.harvard.edu/pph2/</a>). Detailed structure models of human Cx30 and Cx31 proteins are currently not defined.</div>

The Scientific World Journal

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Figure 1: Comparison of Predictive<i> In Silico</i> Tools on Missense Variants in<i> GJB2</i>,<i> GJB6</i>, and<i> GJB3</i> Genes Associated with Autosomal Recessive Deafness 1A (DFNB1A) 

Figure 1 | Comparison of Predictive In Silico Tools on Missense Variants in GJB2, GJB6, and GJB3 Genes Associated with Autosomal Recessive Deafness 1A (DFNB1A) 