Effect of Nigella sativa Supplementation on Oxidative Stress and Antioxidant Parameters: A Meta-Analysis of Randomized Controlled Trials

Table 1

Characteristics of the included studies.

Author	Year	Study design	Target population	NS form	Dose/day	Duration	Gender	Age	Sample size	Outcome	Jadad score
Hadi et al. [14]	2018	Randomized, double-blind, placebo-controlled trial	DM type 2	Oil capsule	500 mg	8 weeks	Female	30–60	43	MDA, SOD, TNF-α, IL-1β, CAT, NO	3
Hadi et al. [13]	2016	Randomized, double-blind, placebo-controlled trial	Rheumatoid arthritis	Oil capsule	500 mg	8 weeks	Female	20–50	39	MDA, TAC, SOD, TNF-α, IL-10, CAT, NO	4
Kaatabi et al. [17]	2015	Randomized, participant blind, placebo-controlled trial	DM type 2	Powder capsule	2 gr	48 weeks	Both	18–60	114	TAC, SOD, FBG, HbA1c, C-peptide, insulin resistance, beta-cell activity, CAT, glutathione, TBARS	3
Nikkhah-Bodaghi et al. [16]	2019	Randomized, double-blind, placebo-controlled trial	Ulcerative colitis	Powder capsule	500 mg	6 weeks	Both	>18	48	MDA, TAC, TNF-α, hs-CRP, NFkB	4
Namazi et al. [15]	2015	Randomized, double-blind, placebo-controlled trial	Obese	Oil capsule	3 gr	8 weeks	Female	25–50	49	MDA, TAC, SOD, GPx	4