Z-Guggulsterone Induces Apoptosis in Gastric Cancer Cells through the Intrinsic Mitochondria-Dependent Pathway

Figure 1

Z-guggulsterone, an FXR antagonist, exhibited cytotoxicity in SGC-7901 cells. (a) Cells were incubated with 0 and 50 µM z-guggulsterone. FXR and SHP protein levels were assessed by western blotting. Quantification of protein bands are shown in the bottom panels. β-Actin was used as a control. Data are expressed as means ± SD. vs. untreated cells. (b) Cells were incubated with 0, 15, 50, and 75 μM z-guggulsterone, and cell survival was investigated using MTT assay. Data are expressed as means ± SD. vs. untreated cells. Z-gug, z-guggulsterone.

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