Time to First-Line Antiretroviral Treatment Failure and Its Predictors among HIV-Positive Children in Shashemene Town Health Facilities, Oromia Region, Ethiopia, 2019

Table 4

Bivariable Cox regression analysis for clinical determinants of survival among children who started ART at public health facilities between January 1, 2011, to December 30, 2015, at Shashamene town, Oromia region, Ethiopia.

Variables	Category	No. (%)	CHR (95% CI)	value
Cotrimoxazole prophylaxis initiation	Yes	383 (92.5)	1
	No	31 (7.5)	0.96 (0.39–7.27)	0.97
Isoniazide prophylaxis initiation	Yes	202 (48.8)	1
	No	211 (51)	1.53 (.59–3.92)	0.37
Baseline Hgb status	Anemia	85 (20.5)	3.87 (1.42–10.57)	0.01
	Normal	319 (77.1)	1
TB result	Positive	90 (21.7)	2.18 (0.89–5.36)	0.08
	Negative	303 (73.2)	1
Baseline CD4 count	Below threshold level	128 (30.9)	4.37 (1.37–11.14)	0.002
	Normal	286 (69.1)	1
Baseline WHO stage	Nonadvanced stage (stages 1 and 2	271 (65.5)	1
	Advanced stage (stages 3 and 4)	143 (34.5)	5.35 (2.0–14.30)	0.001
Baseline nutritional status	Z score > −2	143 (34.5)	1
	Z score ≤ −2	24 (5.8)	1.43 (.28–7.84)	0.66
	BMI < 16 kg/m^2	271 (65.5)	1.59 (0.64–4.07)	0.33
	BMI ≥ 16 kg/m^2	143 (34.5)	1
Exposure status for PMTCT	Exposed	132 (31.9)	1.23 (0.48–3.15)	0.66
	Not exposed	197 (47.6)	1
Regime	Nonnevirapine	172 (41.5)	1
	Nevirapine	240 (58.0)	2.43 (1.04–5.67)	0.04
Adherence	Good	251 (60.6)	1
	Fair	82 (19.8)	0.646 (0.13–3.29)	0.6
	Poor	81 (19.6)	1.349 (0.39–4.61)	0.63