Validating the Hypoglycaemic and Hypotensive Roles of Salvia serotina (Chicken Weed) in Normal Healthy Sprague–Dawley Rats

Table 2

The effects of crude extracts from Salvia serotina L. on SBP, DBP, and MAP when administered intravenously at 50 mg/kg BW in normotensive S–D rats. (n = 6). .

Experimental group	Blood pressure (mm·Hg)	Time (min)
		0	5	10	15	20
DMSO control	SBP	129 ± 4	140 ± 8	156 ± 4	156 ± 3	152 ± 4
MeOH extract		119 ± 3	120 ± 6	135 ± 11	142 ± 8	144 ± 8
EtOAc extract		122 ± 3	147 ± 7	153 ± 4	154 ± 6	161 ± 6
Hexane extract^a		123 ± 4	130 ± 8	132 ± 4	129 ± 3	132 ± 4
DMSO control	DBP	96 ± 8	114 ± 9	132 ± 8	136 ± 4	129 ± 6
MeOH extract		92 ± 4	103 ± 7	119 ± 12	123 ± 7	129 ± 8
EtOAc extract		91 ± 5	120 ± 9	126 ± 5	131 ± 5	131 ± 4
Hexane extract^b		83 ± 6	104 ± 8	106 ± 7	103 ± 6	104 ± 7
DMSO control	MAP	106 ± 6	123 ± 9	140 ± 6	142 ± 3	137 ± 5
MeOH extract		107 ± 6	107 ± 7	124 ± 12	129 ± 8	133 ± 8
EtOAc extract		101 ± 5	129 ± 8	135 ± 4	138 ± 6	141 ± 4
Hexane extract^c		96 ± 4	112 ± 7	115 ± 7	111 ± 7	113 ± 7

Note. SBP – systolic blood pressure, DBP – diastolic blood pressure, MAP – mean arterial pressure, DMSO – dimethyl sulfoxide, MeOH – methanol, and EtOAc – ethyl acetate. ^aThe hexane extract significantly lowered the SBP at the 10 and 15 minutes intervals ( and , respectively). ^bThe hexane extract significantly lowered the DBP at the 10 and 15 minutes intervals and , respectively. ^cThe hexane extract significantly lowered the MAP at the 10 and 15 minutes intervals ( and , respectively).