Computational Identification of Most Deleterious Missense Mutations in Human PD-1 Gene

Table 1

Shortlisting of the most probable disease-associated missense variants.

Tools	R38C	D61V	R94C	D117V
SIFT	0; (Deleterious)	0; (Deleterious)	0; (Deleterious)	0; (Deleterious)
PolyPhen-2	0.999; (Probably damaging)	0.998; (Probably damaging)	1; (Probably damaging)	1; (Probably damaging)
MutationAssessor	0.953; (High)	0.955; (High)	0.953; (High)	0.955; (High)