Computational Identification of Most Deleterious Missense Mutations in Human PD-1 Gene

Table 2

Sequence-based predictions of the top 4 missense variants.

Tools	R38C	D61V	R94C	D117V
SNAP2	−14; (Neutral)	26; (Effect)	71; (Effect)	83; (Effect)
MutPred 2	0.109; (Neutral)	0.259; (Neutral)	0.768; (Pathogenic)	0.805; (Pathogenic)
SNP&GO	7; (Neutral)	3; (Neutral)	3; (Neutral)	3; (Disease)
SuSPect	69; (Disease-associated)	15; (Neutral)	91; (Disease-associated)	12; (Neutral)
PANTHER	0.27; (Probably benign)	0.27; (Probably benign)	0.27; (Probably benign)	0.5; (Possibly damaging)
PMut	0.07; (Neutral)	0.11; (Neutral)	0.45; (Neutral)	0.69; (Disease)
DEOGEN	0.85; (Deleterious)	0.64; (Deleterious)	0.87; (Deleterious)	0.89; (Deleterious)

Numbers indicate the probable mutation effect score, while bold indicates deleterious mutations.