Assessment of Efficacy and Toxicity of Cyclophosphamide Chemotherapy in Canines with Malignant Mammary Tumor: A Retrospective Study

Table 1

Mean ± SE values of haemato-biochemical parameters in dogs with malignant mammary tumor prior to and after cyclophosphamide chemotherapy in group II dogs.

Haemato-biochemical parameters	0^th day (before treatment)	1^st day (I^st dose of chemotherapy)	3^rd day	7^th day (II^nd dose of chemotherapy)	14^th day (III^rd dose of chemotherapy)	21^st day
TEC (10^6/cumm)	6.38 ± 0.12	5.82 ± 0.11	5.26 ± 0.56	6.23 ± 0.22	7.05 ± 0.15	7.38 ± 0.09
Hb (gm %)	13.8 ± 0.25	11.6 ± 0.36	11.9 ± 0.33	11.8 ± 0.20	12.6 ± 0.18	13.1 ± 0.07
PCV (%)	37.2 ± 0.55	35.7 ± 0.30	36.1 ± 0.47	35.1 ± 0.48	35.9 ± 0.33	36.6 ± 0.36
TLC (thousand/cumm)	15.7 ± 0.44	15.9 ± 0.31	13.8 ± 0.45	16.8 ± 0.45	16.3 ± 0.53	14.6 ± 0.27
Platelet (lakh/cumm)	2.66 ± 0.1	1.55 ± 0.06	1.48 ± 0.07	1.57 ± 0.06	1.51 ± 0.08	1.56 ± 0.10
AST (IU/L)	37.4 ± 0.60	38.3 ± 0.34	38.1 ± 0.26	38.6 ± 0.34	38.1 ± 0.32	37.5 ± 0.42
ALT (IU/L)	38.5 ± 0.11	47.4 ± 0.52	47.1 ± 0.28	47.6 ± 0.19	47.5 ± 0.29	47.3 ± 0.10
BUN (mg/dl)	20.4 ± 0.58	21.9 ± 0.49	22.8 ± 0.39	24.9 ± 0.38	27.1 ± 0.13	25.9 ± 0.68
Serum creatinine (mg/dl)	1.11 ± 0.04	1.41 ± 0.06	1.56 ± 0.02	1.65 ± 0.03	1.47 ± 0.05	1.56 ± 0.02