Drug Interaction between Dexamethasone and Ketoprofen with Thiopental in Male Dogs: Effect on the Recovery from Anesthesia and Pharmacokinetics Parameters

Table 1

Biochemical and hematological parameters evaluated in the controlled and treated groups.

Parameters	Mean ± SEM control	Mean ± SEM T1	Mean ± SEM T2	value	Normal range
W.B.C × 10^3 (meq/l)	12.5 ± 2.2	11.33 ± 3.4	10.5 ± 2.6	0.343	6–17
R.B.C × 10^6 (meq/l)	6.59 ± 1.98	7.49 ± 1.8	6.22 ± 1.47	0.964	4–9
HGB (g/dl)	16.9 ± 1.87	16.6 ± 2.6	17.3 ± 1.9	0.562	12–18
HCT (%)	49.3 ± 3.80	43.5 ± 2.25	50.3 ± 5.72	0.256	37–55
M.C.V (fl)	64.7 ± 2.60	65.3 ± 1.45	66.3 ± 4.65	0.363	60–72
M.C.H.C (pg)	21.4 ± 1.31	22.4 ± 1.70	23.4 ± 1.92	0.671	19.5–25.5
PLATELET × 10^3 (meq/l)	467.6 ± 45.31	470.3 ± 26.32	480.29 ± 28.27	0.384	200–500
Neutrophil (%)	66.56 ± 10.2	63.2 ± 5.78	65 ± 9.31	0.223	60–77
Lymphocyte (%)	19.3 ± 3.12	19.5 ± 3.42	20.3 ± 7.83	0.652	12–30
Monocytes (%)	2.8 ± 1.32	3.0 ± 1.46	2.9 ± 1.15	0.423	3–10
Eosinophil (%)	0.1 ± 0.01	0.1 ± 0.32	0.1 ± 0.13	0.281	0.1–1.3
Basophil (%)	0.25 ± 0.12	0.1 ± 0.10	0.1 ± 0.47	0.572	0–0.5
AST (U/L)	27.4 ± 13.4	26.5 ± 15.2	25.34 ± 12.5	0.342	10–34
ALT (U/L)	43.35 ± 10.67	44.56 ± 15.8	41.0 ± 13.46	0.195	7–70
Urea (mg/dl)	27.16 ± 11.7	29.16 ± 8.7	26.22 ± 5.15	0.148	17–38
Creatinine (mg/dl)	0.8 ± 0.39	0.7 ± 0.47	0.9 ± 0.65	0.210	0.3–1.7
Total protein (g/l)	52.3 ± 3.7	54.3 ± 4.89	50.4 ± 4.67	0.231	50–78