Drug Interaction between Dexamethasone and Ketoprofen with Thiopental in Male Dogs: Effect on the Recovery from Anesthesia and Pharmacokinetics Parameters

Table 4

Changes in body weight and thiopental pharmacokinetic parameters in the studied groups.

Groups	Weight (kg)			(L h^−1 kg^−1)	Cl (Lh^−1)
Control	21.34 ± 0.330	0.72 ± 0.006	9.17 ± 0.074	2.81 ± 0.038	2.10 ± 0.020
T1	21.18 ± 0.23	0.61 ± 0.004 a	13.38 ± 0.181 a	3.41 ± 0.026 a	2.09 ± 0.019
T2	21.23 ± 0.24	0.71 ± 0.005 b	9.24 ± 0.23 b	2.74 ± 0.021 b	2.02 ± 0.024

Each column contains the mean ± standard error of the mean (mean ± SEM) and represents a, b, and c, respectively, compared to the control, T1, and T2 groups. , . k_el: elimination rate constant, : half-life, : volume of distribution, Cl: clearance.