Evaluation of the Pro-, Anti-Inflammatory, and Anabolic Effects of Autologous Platelet-Rich Gel Supernatants in an in vitro Coculture System of Canine Osteoarthritis

Figure 3

Biomolecule concentrations in both hemocomponents, platelet-poor gel supernatant (PPGS), and platelet-rich gel supernatant (PRGS). (a) Mean (±SD) interleukin 1 beta (IL-1β) concentrations in PPGS and PRGS. (b) Mean (±SD) interleukin 10 (IL-10) concentrations in PPGS and PRGS. (c) Mean (±SD) hyaluronan (HA) concentrations in PPGS and PRGS. (d) Mean (±SD) transforming growth factor beta 1 (TGF-β₁) concentrations in PPGS and PRGS. (e) Mean (±SD) platelet-derived growth factor isoform BB (PDGF-BB) concentrations in PPGS and PRGS. Different lower-case letters represent significant differences between hemocomponents for biomolecules. HA, hyaluronan; IL, interleukin; LPS, lipopolysaccharide; PLT, platelet; PDGF-BB, platelet-derived growth factor isoform BB; PPP/PPGS, platelet-poor plasma/platelet-poor gel supernatant; PRP/PRGS, platelet-rich plasma/platelet-rich gel supernatant; TGF-β₁, transforming growth factor beta 1; WBC, white blood cell.

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