Activating Mutation in the Receptor Tyrosine Kinase FLT3 with Clinicopathological Relevance in Canine Mast Cell Tumors

Table 3

Comparison of clinicopathological characteristics between FLT3-ITD mutation and FLT3-WT of JM domain from 20 MCT dogs at the time of diagnosis.

	Total	FLT3-WT	FLT3-ITD
No. of MCT dogs (%)	20	6 (30)	14 (70)
Median age (years)	10.5	10.5	11	0.7897
Sex				0.1731
M	12	4	8
Mc	2	0	2
F	4	3	1
Fs	2	0	2
Histologic grading				0.7686
Low	9	3	6
High	11	3	8
Laboratory findings
Median WBC count (×10^3/µl) (range)	13.19 (4.04–34.54)	10.21 (4.04–11.25)	15.62 (6.22–34.50)	0.0035
Median neutrophil count (×10^3/µl) (range)	10.05 (3.23–31.74)	8.41 (3.23–9.53)	11.80 (4.71–31.74)	0.0033
Median lymphocyte count (×10^3/µl) (range)	1.82 (1.5–4.47)	1.01 (0.55–1.94)	2.09 (0.15–4.47)	0.05
Median monocyte count (×10^3/µl) (range)	0.73 (0.08–1.88)	0.44 (0.08–0.99)	0.7 (0.24–0.188)	0.2269
Median eosinophil count (×10^3/µl) (range)	0.27 (0–0.9)	0.15 (0–0.45)	0.33 (0–0.9)	0.0752
Median PCV (%) (range)	36.9 (28.4–49.2)	41.15 (29–47.9)	34.3 (28.4–49.2)	0.3017
Median platelet count (×10^3/µl) (range)	249 (148–487)	270 (148–487)	244 (1560–4 36)	0.8374
Median hemoglobin (g/dl) (range)	12.45 (9.2–18.6)	13.95 (10.4–17.9)	11.9 (9.2–18.6)	0.5062
Mastocytemia (%)	2 (10)	1 (10)	1 (10)

M = male, Mc = castrated male, F = female, Fs = spayed female, PCV = packed cell volume Statistically significant.