Research Article
Intra-Articular AAV9 α-L-Iduronidase Gene Replacement in the Canine Model of Mucopolysaccharidosis Type I
Figure 7
Synovial photomicrographs and lysosomal storage scoring in the high-dose +2 w animal. Baseline synoviocytes demonstrate lysosomal storage (red arrows, scored 1). At necropsy, AAV9-eGFP treated joint capsule showed increased lysosomal storage (scored 2), while AAV9-IDUA-treated synoviocytes scored 0. The latter also demonstrated a lymphocytic infiltrate (blue ellipse). Control synovium included for comparison. μM.