Research Article
Intra-Articular AAV9 α-L-Iduronidase Gene Replacement in the Canine Model of Mucopolysaccharidosis Type I
Figure 8
Cartilage HS levels in the (a) high-dose +2 w, (b) high-dose +52 w, and (c) low-dose +52 w animals. HS is only reduced in AAV9-IDUA-treated cartilage of the high-dose +2 w dog. In all other joints, cartilage HS was higher at necropsy than at baseline.
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