Research Article
Intra-Articular AAV9 α-L-Iduronidase Gene Replacement in the Canine Model of Mucopolysaccharidosis Type I
Figure 9
Cartilage DS levels in the (a) high-dose +2 w, (b) high-dose +52 w, and (c) low-dose +52 w animals. Cartilage DS levels in all treated animals were greater at necropsy than baseline. Only DS from the AAV9-IDUA shoulder of the high-dose +2 w animal was comparable to wild-type cartilage.
(a) |
(b) |
(c) |