T Cell Roles and Activity in Chronic Sclerosing Sialadenitis as IgG4-Related Disease: Current Concepts in Immunopathogenesis
Table 3
Diagnostic criteria of IgG4+ mikulicz’s disease (approved by the Japanese Society for Sjögren’s Syndrome 2008) [131].
Symmetrical swelling of at least two pairs of lachrymal, parotid, or submandibular glands for at least 3 months
AND Elevated serum IgG4 (>135 mg/dL)
OR Histopathological features including lymphocyte and IgG4+plasma cell infiltration (IgG4+ plasma cells/IgG+ plasma cells > 50%) with typical tissue fibrosis or sclerosis.