Gut Microbiome: An Intersection between Human Genome, Diet, and Epigenetics

Figure 3

Relationship between ATG16L1 and gut microbiota. (a) ATG16L1 gene variant has been associated with loss of microbiota recognition, abnormal levels of IgA and IgG, altered CD4+ T cell recognition, and a defective production of antimicrobials. These are known to develop gut dysbiosis that causes several disease conditions. (b) The same gene variant is known to cause poor antigen presentation and impaired bacterial clearance which results in gut dysbiosis that has been associated with Crohn’s disease.