Gut Microbiome: An Intersection between Human Genome, Diet, and Epigenetics

Figure 4

Common pathways between gene variants. (a) Both the NOD2 gene and MUC gene variants are known to cause defective mucosal barriers that result in gut dysbiosis. However, the gut dysbiosis resulting from the NOD2 gene is associated with colitis, while that of the MUC gene is associated with UC. (b) Similarly, the NOD2 gene and ATG16L1 gene variants both cause an ineffective clearance of pathogens in the gut that leads to gut dysbiosis. Although NOD2 is associated with IBD, ATG16L1 is associated with CD.

(a)

(b)