Gut Microbiome: An Intersection between Human Genome, Diet, and Epigenetics

Table 1

Gene variants and their associated microbiota.

Gene	Microbiota	Related condition	References
NOD2	Increase Escherichia spp. and decrease Faecalibacterium spp.	IBD	[35]
NOD2/ATG16L1	Increase Bacteroides fragilis	IBD	[51]
UBR3	Increase Rikinellaceae spp.	Dysregulation of the protein ubiquitination pathway	[72]
PLD1 & LINGO2	Increase Akkermansia and Blautia spp.	Obesity	[72]
SLIT3	Increase Clostridiaceae and Dermococcus spp.	Inflammation and obesity	[2]
VDR3	Increase Parabacterioides spp.	Dysregulation of bile synthesis	[94]
ALDH1AL1	Increase Christensenelleceae spp.	Dysregulation of xenobiotic metabolism	[2]
PTN2 & PTN22	Increase Faecalibacterium, Bilophilia, and Coprococcus spp.	T1D	[83, 85]
DR3/4	Increase Bacteroides, Parabacteroides, Clostridium, Klebsiella, and Akkermansia spp.	T1D	[89]