Estimates and Predictors of Mortality, Stroke Recurrence, and Functional Dependency 1-Year after Ischemic Stroke: A Prospective Multicenter Longitudinal Cohort Study in Central Norway

Table 2

Cox age-adjusted and multivariable proportional hazards models for death. In the multivariable models, the total number of available cases was and events .

Characteristic	Age-adjusted			Multivariable model 1			Multivariable model 2
	HR^1	95% CI^2	value	HR^1	95% CI^2	value	HR^1	95% CI^2	value
Age (years)	1.11	1.07-1.14	<0.001	1.07	1.03-1.10	<0.001	1.07	1.03-1.11	<0.001
Male	1.30	0.78-2.18	0.30	1.33	0.73-2.43	0.30	1.50	0.82-2.74	0.20
Modified Rankin scale
Dependent 3-4	0.88	0.47-1.61	0.70	0.61	0.31-1.20	0.20	0.50	0.25-1.00	0.05
Stroke etiology			0.045
Small vessel occlusion	—	—
Large artery atherosclerosis	2.97	1.06-8.36
Cardioembolism	3.67	1.38-9.76
Stroke of other determined etiology	3.53	1.02-12.20
Stroke of undetermined etiology	2.21	0.80-6.11
Complications during hospital stay	3.31	1.99-5.52	<0.001
Thrombolysis	1.85	1.06-3.21	0.030
NIHSS day 1^†	1.10	1.07-1.13	<0.001	1.10	1.07-1.13	<0.001	1.09	1.06-1.12	<0.001
Charlson comorbidity burden			<0.001						<0.001
0—none	—	—					—	—
1—low	4.05	1.48-11.10					5.56	1.94-15.90
2-3—moderate	5.44	2.06-14.40					6.82	2.49-18.60
4 or more—high	7.75	2.85-21.00					6.89	2.44-19.50
Atrial fibrillation	1.63	0.97-2.74	0.065	1.04	0.58-1.87	0.90	0.96	0.52-1.78	0.90
Antihypertensive	0.90	0.53-1.51	0.70	0.71	0.40-1.26	0.20	0.61	0.34-1.10	0.10
Statin therapy	0.40	0.22-0.71	0.002	0.39	0.21-0.75	0.004	0.39	0.20-0.76	0.006
Diabetes mellitus	1.20	0.65-2.21	0.60	1.39	0.70-2.76	0.30
Current smoker	1.06	0.50-2.27	0.90
CAD^§	1.79	1.06-3.02	0.029	2.40	1.32-4.38	0.004

¹HR = hazard ratio; ²CI = confidence interval. ^†National Institutes of Health Stroke Scale (NIHSS). ^§Coronary artery disease (CAD).