Research Article

Potential Targets and Signaling Mechanisms of Cinnamaldehyde Enhancing Intestinal Function and Nutritional Regulation in Fat Greenling (Hexagrammos otakii)

Figure 7

Inflammation system interaction of the Kyoto Eencyclopedia of genes and genomes (KEGG) enrichment pathway terms and putative target protein (PTP) in the intestinal inflammation disease (IIF) of H. otakii and cinnamaldehyde. Cinnamaldehyde may restrict C5/C5aR1/IL-6 and TLR4/NFκB/PTGS2 pathway by limiting the C5, C5aR1, and IL-6, and also inhibits TLR4, MyD88, NFκB, and primary inflammatory cytokines (TNF-a and PTGS2), that can help to relive the intestinal inflammation and maintaining intestinal function.