Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral <i>Sinularia sandensis</i> through the MAPKs Pathway on Oral Cancer Cells

<div>4-Carbomethoxyl-10-epigyrosanoldie E suppressed the expressions of MMP-2, MMP-9, and uPAR protein and augmented the expressions of TIMP-1 and TIMP-2 protein. The expression levels of MMP-2, MMP-9, uPAR, TIMP-1, and TIMP-2 were analyzed by Western blotting. The total cell lysates of Cal-27 and Ca9-22 cells treated with 4-carbomethoxyl-10-epigyrosanoldie E, respectively, were analyzed. C means cells were treated with DMSO vehicle only. <i>β</i>-Actin was used as the protein loading control.</div>

Advances in Pharmacological and Pharmaceutical Sciences

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Figure 2

Figure 2: Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral <i>Sinularia sandensis</i> through the MAPKs Pathway on Oral Cancer Cells 

Figure 2 | Suppression of Migration and Invasion by 4-Carbomethoxyl-10-Epigyrosanoldie E from the Cultured Soft Coral Sinularia sandensis through the MAPKs Pathway on Oral Cancer Cells 