Research Article
New Organotin (IV) Compounds Derived from Dehydroacetic Acid and Thiosemicarbazides: Synthesis, Rational Design, Cytotoxic Evaluation, and Molecular Docking Simulation
Figure 12
Diorganotin complexes induced morphological changes in the MDA-MB-231 breast cancer cell line. Giemsa stain of cells incubated with different organotin (IV) complexes concentrations for 48 h. Cell size reduction, rounding and pyknotic nuclei (black arrows), cytoplasm vacuolization (3e, box), chromatin condensation (3d, box), apoptotic bodies (star), cell lysis and necrosis (+). Bar: 20 µm (20x).