New Tin (IV) and Organotin (IV) Complexes with a Hybrid Thiosemicarbazone/Hydrazone Ligand: Synthesis, Crystal Structure, and Antiproliferative Activity

Figure 9

Dose-dependent disruption in mitochondrial membrane permeability (MMP) in MDA-MB-231 cells treated with complex 3. Post treatment with 3 (0.25 µM, 0.5 µM, and 1 µM) for 24 h, cells were stained with JC1. (a) fluorescence microscopic analysis, and (a) and (b) fold increase in JC1 aggregate/JC1 monomer fluorescence intensity ratio. (c) FACS analysis and (d) percentage of JC1 aggregate and JC1 monomer cell population.

(a)

(b)

(c)

(d)