New Tin (IV) and Organotin (IV) Complexes with a Hybrid Thiosemicarbazone/Hydrazone Ligand: Synthesis, Crystal Structure, and Antiproliferative Activity

Table 1

Comparative IC₅₀ values of L¹H₂, [L¹H₃]Cl, 1, 2, 3, and 4 (0–5 µM) in cancer cell lines MDA-MB-231, HeLa, PC3, and HepG2 and normal lung fibroblast cell line WI-38.

Compounds	HeLa	MDA-MB231	HepG2	PC3	WI-38
L^1H2	1.06 ± 0.21	2.42 ± 0.33	5.14 ± 0.52	4.86 ± 0.75	10.78 ± 0.96
[L^1H3]Cl	1.49 ± 0.46	2.48 ± 0.47	6.27 ± 0.98	3.49 ± 0.73	14.09 ± 0.48
1	2.22 ± 0.54	3.54 ± 0.34	4.97 ± 0.76	2.76 ± 0.52	15.63 ± 0.73
2	0.78 ± 0.27	1.038 ± 0.21	2.46 ± 0.42	2.58 ± 0.36	12.02 ± 0.89
3	0.43 ± 0.18	0.51 ± 0.13	1.59 ± 0.17	1.97 ± 0.24	15.69 ± 0.28
4	2.19 ± 0.36	1.78 ± 0.26	3.73 ± 0.43	4.29 ± 0.29	14.38 ± 0.28
Cisplatin	3.26 ± 0.23	8.25 ± 1.64	11.49 ± 2.06	5.36 ± 1.24	20.56 ± 1.52