A Unique Combination of Mn²⁺ and Aluminum Adjuvant Acted the Synergistic Effect

Figure 2

Evaluation of cytokine from splenocytes. Seven days after the last immunization, splenocytes from each group were stimulated with IsdB3 proteins, and the levels of IFN-γ, IL-4, IL-10, and IL-17 in the supernatant were detected by the ELISA method. The splenocyte response for IFN-γ (a), IL-4 (b), IL-10 (c), and IL-17 (d). The statistical differences between the groups are shown as , , and . The data are shown as the mean ± SD (n = 3).

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(b)

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(d)