Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases

Figure 1

The regulatory mechanism of ferroptosis. The regulatory mechanisms of ferroptosis include iron metabolism, lipid peroxidation and ROS metabolism, cystine/glutamate antiporter, and glutathione peroxidase 4. The different mechanisms interact with each other. ROS: reactive oxygen species; POR: cytochrome P450 oxidoreductase; CYB5R1: NADH-cytochrome b5 reductase; PUFA: polyunsaturated fatty acids; SLC7A11: solute carrier family 7 member 11; SLC3A2: solute carrier family 3 member 2; ATF3: activating transcription factor 3; GSH: glutathione; GSSG: oxidized glutathione; GPX4: glutathione peroxidase 4.