Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases

Figure 2

Ferroptosis and pulmonary infection caused by Pseudomonas aeruginosa. The PA without AA-PE produces pLoxA to transform the AA-PE contained in human bronchial epithelial cells into 15-hydrogenation oxygen-AA-PE, which produces ROS, thereby resulting in ferroptosis of host bronchial epithelial cells. NO∙ produced by macrophages inhibits PA to induce ferroptosis by inhibiting phospholipid peroxidation, especially by producing 15-hydrooxidation-AA-PE signal. PA generates proferroptotic signal 15-HPET-PE through 15-lipoxygenase. PA: Pseudomonas aeruginosa; AA-PE: arachidonic acid-phosphatidyl ethanolamine; pLoxA: lipoxygenase; 15-HOO-AA-PE: 15-hydrogenation oxygen-AA-PE; ROS: reactive oxygen species.