Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases

Table 2

Ferroptosis-associated genes associated with pulmonary infection.

Gene	Infectious factor	Function
GPX4	MTB	Decreased GPX4 levels lead to acute lung necrosis induced by MTB and thus host macrophage death
	SARS-CoV-2	Reduces LPO in biofilms
	Leishmania spp	GPX4-deficient T lymphocytes have difficulty resisting pulmonary infections caused by leishmaniasis
SOCS1	MTB	As a biomarker for the diagnosis and treatment of MTB
ACSL1	SARS-CoV-2	Inhibits syncytial formation and viral transmission in primary macrophages; reduces lung inflammation and injury

GPX4: glutathione peroxidase 4; SOCS1: suppressor of cytokine signaling1; ACSL1: acyl-CoA synthetase long-chain family member 1; MTB: Mycobacterium tuberculosis; SARS-CoV-2: severe acute respiratory syndrome coronavirus type 2; LPO: lipid peroxides.