Review Article
Ferroptosis Is a Potential Therapeutic Target for Pulmonary Infectious Diseases
Table 3
The inhibitors of ferroptosis.
| | Compounds | Mechanisms | Special effect |
| | DFO | Inhibit accumulation of iron | DFO completely blocks IL-6 production after SIRS, delaying SIRS and circulatory collapse | | CPX | Inhibit accumulation of iron | NA | | 2,2-pyridine | Inhibit accumulation of iron | NA | | Fer-1 | Remove ROS, inhibit lipid peroxidation | Fer-1 inhibits the process of host macrophage death induced by MTB in acute lung necrosis | | Lip-1 | Remove ROS, inhibit lipid peroxidation | Lip-1 can synergize with rifampicin to enhance its antibacterial effect against Klebsiella pneumoniae | | Vitamin E | Compensate GPX4 loss | Vitamin E supplementation has been shown to increase resistance to respiratory infections | | Curcumin | Prevent GSH depletion and lipid peroxidation | NA | | EGCG | Prevent GSH depletion and lipid peroxidation | NA | | Baicalein | Prevent GSH depletion and lipid peroxidation | NA | | NDGA | Prevent GSH depletion and lipid peroxidation | NA |
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CPX: ciclopirox; DFO: deferoxamine; EGCG: (-)-epigallocatechin-3-gallate; Fer-1: ferrostatin 1; GSH: glutathione; GPX4: glutathione peroxidase 4; Lip-1: liproxstatin-1; NDGA: nordihydroguaiaretic acid; IL-6: interleukin-6; SIRS: systemic inflammatory response syndrome; ROS: reactive oxygen species.
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