Dual Control of Host Actin Polymerization by a Legionella Effector Pair

Figure 5

LegK2/VipA effector pair but also other actin-related effectors, Ceg14, RavK, and WipA, are strongly conserved in the L. pneumophila species. (a) Phylogenetic tree representing the phylogenetic diversity of Legionella genomes displaying either LegK2 (name of species written in blue), VipA (written in purple), Ceg14 (green squares), RavK (yellow squares), and WipA genes (dark blue). The squares are filled when the genes have been found in the corresponding genome and empty when genes have not been detected. (b) Distribution of the 5 actin-polymerization related effectors from Legionella pneumophila in 647 different Legionella strains including L. pneumophila and non-pneumophila strains. The protein sequence of the effector of L. pneumophila strain was blasted against our genome database of family-clustered proteins to determine the presence or absence of proteins in the corresponding genomes.

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