Prolonged Disease Course of COVID-19 in a Patient with CTLA-4 Haploinsufficiency

Table 2

SARS-CoV-2 PCR test results, anti-SARS-CoV-2 antibody levels, and convalescent plasma infusions.

Days after start of first symptoms of COVID-19	Protective antibody level	Antibody level (A/CO)	SARS-CoV-2 PCR	Ct-value	Sample
7			Positive	24.6	Oropharynx
20			Positive	30.8	Oropharynx
25	Negative	0.020
32			Negative	NA	Bronchial washing
33			Positive	NA	Nasopharynx
49			Positive	NA	Nasopharynx
61			Positive	29.7	Sputum
83			Positive	23.8	Oropharynx
88	Negative	0.024
89		First transfusion of convalescent plasma
89	Positive	4.830
91			Positive	NA	Oropharynx
94			Positive	32.4	Oropharynx
96	Negative	0.527
98	Negative	0.381
101			Positive	28.1	Oropharynx
103		Second transfusion of convalescent plasma
110	Positive	9.083	Positive	27.6	Oropharynx
116	Positive	10.203	Positive	38.9	Oropharynx
119		Third transfusion of convalescent plasma
123	Positive	7.437	Negative	NA	Oropharynx
126			Positive	28.9	Oropharynx
130			Negative	NA	Oropharynx
131	Positive	4.523
133		Fourth transfusion of convalescent plasma
136			Positive	NA	Oropharynx
137	Positive	13.935	Positive	36.8	Oropharynx
143	Positive	12.567
144			Negative	NA	Oropharynx
146			Negative	NA	Oropharynx
146		Fifth transfusion of convalescent plasma
153			Negative	NA	Oropharynx
165	Positive	>14	Negative	NA	Oropharynx
165		Sixth transfusion of convalescent plasma
181	Positive	>14	Negative	NA	Oropharynx
196			Negative	NA	Oropharynx
207	Positive	10.602
236	Positive	4.050	Negative	NA	Oropharynx
275			Negative	NA	Oropharynx
291		First SARS-CoV-2 vaccine
300	Negative	<3.80 (IgG (AU/mL))
319		Second SARS-CoV-2 vaccine
384	Negative	<1.85 (IgG (AU/mL))
414			Negative	NA	Oropharynx
417	Negative	<1.85 (IgG (AU/mL))
553			Negative	NA	Sputum

Reference numbers for antibody levels are >1.1 A/CO and >13 AU/mL. Ct = cycle threshold. NA = not available.