Case Report

Prolonged Disease Course of COVID-19 in a Patient with CTLA-4 Haploinsufficiency

Table 2

SARS-CoV-2 PCR test results, anti-SARS-CoV-2 antibody levels, and convalescent plasma infusions.

Days after start of first symptoms of COVID-19Protective antibody levelAntibody level (A/CO)SARS-CoV-2 PCRCt-valueSample

7Positive24.6Oropharynx
20Positive30.8Oropharynx
25Negative0.020
32NegativeNABronchial washing
33PositiveNANasopharynx
49PositiveNANasopharynx
61Positive29.7Sputum
83Positive23.8Oropharynx
88Negative0.024
89First transfusion of convalescent plasma
89Positive4.830
91PositiveNAOropharynx
94Positive32.4Oropharynx
96Negative0.527
98Negative0.381
101Positive28.1Oropharynx
103Second transfusion of convalescent plasma
110Positive9.083Positive27.6Oropharynx
116Positive10.203Positive38.9Oropharynx
119Third transfusion of convalescent plasma
123Positive7.437NegativeNAOropharynx
126Positive28.9Oropharynx
130NegativeNAOropharynx
131Positive4.523
133Fourth transfusion of convalescent plasma
136PositiveNAOropharynx
137Positive13.935Positive36.8Oropharynx
143Positive12.567
144NegativeNAOropharynx
146NegativeNAOropharynx
146Fifth transfusion of convalescent plasma
153NegativeNAOropharynx
165Positive>14NegativeNAOropharynx
165Sixth transfusion of convalescent plasma
181Positive>14NegativeNAOropharynx
196NegativeNAOropharynx
207Positive10.602
236Positive4.050NegativeNAOropharynx
275NegativeNAOropharynx
291First SARS-CoV-2 vaccine
300Negative<3.80 (IgG (AU/mL))
319Second SARS-CoV-2 vaccine
384Negative<1.85 (IgG (AU/mL))
414NegativeNAOropharynx
417Negative<1.85 (IgG (AU/mL))
553NegativeNASputum

Reference numbers for antibody levels are >1.1 A/CO and >13 AU/mL. Ct = cycle threshold. NA = not available.