|
| Reference | Age/sex | Surgery performed | Interval between surgery and infection | Infectious complication | Method of diagnosis | GM status | Antifungal treatment | Outcome |
|
| Index case | 54/F | Neurosurgery/suboccipital craniectomy with C1 laminectomy and duraplasty | 3 weeks | Wound site infection with seroma and epidural abscess with meningitis | Surgical excision, culture | Negative | Voriconazole (loading dose then 350 mg twice a day) for approximately 5 months | Alive. Resolution of epidural abscess |
| Chen et al. [9] | 46/F | Mastoidectomy/craniectomies/chronic otitis media | Approx. 2 years and 5 months | Otogenic cerebellar abscesses | L/CSF; surgery; pus culture | NA | Voriconazole (400 mg/day) for 5 months | Alive |
| Morioka et al. [14] | 83/M | Neurosurgery/burr hole subdural hematoma | Approx. 3 years and 5 months | Subdural abscess and granuloma | Surgical excision histopathology | NA | L-AMB (0.25 biweekly intrathecally) + miconazole (500 mg IV daily); adverse reaction; replaced by flucytosine (5 g orally daily) | NA |
| Darras-Joly et al. [15] | 29/M | Neurosurgery/acoustic neurinoma | NA | Meningitis; abscess | L/CSF | Positive | L-AMB (5 weeks) + 5-FU (7 weeks); itraconazole (6 months) | Alive after 12 months |
| Letscher et al. [16] | 20/M | Frontal craniectomy/brain trauma | NA | Cellulitis/epidural abscess/frontal bone osteomyelitis | Brain biopsy, culture | NA | ABLC × 3 weeks followed by itraconazole for 5 months | Alive after 3 years |
| Endo et al. [17] | 55/M | Neurosurgery/pituitary adenoma | Approx. 1 year | Arachnoiditis; subdural abscess | L/abscess aspiration | ND | AMB + fluconazole (4 weeks) | NA |
| Marinovic et al. [18] | 65/M | Cranioplasty for severe craniofacial trauma | Approx. 8 years | Meningitis, abscess | L/CSF; stereotactic drainage | NA | AMB; L-AMB; itraconazole | Alive |
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