Case Report

Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy following mRNA SARS-CoV-2 Vaccination

Table 1

Published reports of immune-mediated necrotizing myositis and previous vaccination.

AuthorsYearAgeSexTime from vaccination to symptom onsetVaccineTreatment

Cavalcanti et al. [18]202142Female2 weeksYellow fever, tetanus/diphtheria, and hepatitis BPrednisone 1 mg/kg/day
Dodig et al. [19]202155Female21 days after 2nd dosePfizer-BioNTech (BNT162b2 mRNA)Prednisone 30 mg twice; IVIG 1 g/kg; methotrexate 12.5/25 mg daily
Tan et al. [20]202154Male1 week after 2nd doseCoronaVac (Sinovac Biotech)IVIG 2 g/kg followed by oral prednisolone 60 mg daily

IVIG: intravenous immunoglobulin.