Systemic Lupus Erythematosus and Antiphospholipid Syndrome Accompanied by Mixed-Type Autoimmune Hemolytic Anemia

Table 1

Laboratory findings on admission.

Peripheral blood
White blood cell (/μL)	8,000 (3,300–8,600)
Neutrophil (%)	58.6
Eosinophil (%)	1.0
Monocytes (%)	5.2
Lymphocytes (%)	33.2
Red blood cell (×10^6/μL)	1.3 (3.86–4.92)
Hemoglobin (g/dL)	7.2 (11.6–14.8)
Hematocrit (%)	18.4 (35.1–44.4)
Platelet (×10^3/μL)	240 (158–348)
Reticulocytes (%)	298.1 (3–22)
Coagulation study
Prothrombin time (%)	84.3 (>70)
APTT (second)	84.8 (24–37)
Fibrinogen (mg/dL)	219 (150–400)
FDP (μg/mL)	3.4 (<5)
D-dimer (μg/mL)	1.4 (<1)
Blood chemistry
Total protein (g/dL)	6.7 (6.6–8.1)
Albumin (g/dL)	3.2 (4.1–5.1)
Total bilirubin (mg/dL)	6.44 (0.4–1.5)
Direct bilirubin (mg/dL)	0.46 (0–0.3)
Indirect bilirubin (mg/dL)	5.98 (<0.9)
AST (U/L)	32 (13–30)
ALT (U/L)	7 (7–23)
LD (U/L)	513 (124–222)
ALP (U/L)	78 (38–113)
γ-GTP (U/L)	16 (9–32)
Blood urea nitrogen (mg/dL)	21.6 (8–20)
Creatinine (mg/dL)	0.42 (0.46–0.79)
Uric acid (mg/dL)	5.9 (2.6–5.5)
Na (mmol/L)	145 (138–145)
K (mmol/L)	3.3 (3.6–4.8)
Cl (mmol/L)	110 (101–108)
Ca (mg/dL)	8.3 (8.8–10.1)
Fe (μg/dL)	198 (40–188)
UIBC (μg/dL)	23 (155–350)
TIBC (μg/dL)	221 (250–410)
Ferritin (ng/mL)	218.8 (4.6–204)
TSH (μIU/mL)	1.39 (0.35–4.94)
Free-T4 (ng/dL)	1.1 (0.7–1.48)
Vitamin B12 (pg/mL)	375 (233–914)
Folic acid (ng/mL)	3.8 (3.6–12.9)
sIL-2R (U/mL)	816 (127–582)
BNP (pg/mL)	143.1 (<18.4)
KL-6 (U/mL)	583 (<500)
CRP (mg/dl)	0.11 (0–0.14)
Serological study
IgG (mg/dL)	1,725 (861–1,747)
IgA (mg/dL)	424 (93–393)
IgM (mg/dL)	391 (50–269)
C3 (mg/dL)	25.9 (73–138)
C4 (mg/dL)	1.9 (11–31)
Rheumatoid factor (IU/mL)	113 (<15)
Cold agglutinin (fold)	512 (<64)
Cryoglobulin	+
Antinuclear Ab (fold)	640 (<40)
Speckled cytoplasmic
Anti-ds-DNA Ab (IU/mL)	1.7 (<12)
Anti-Sm Ab	−
Anti-RNP Ab	−
Anti-SS-A Ab	−
Anti-SS-B Ab	−
Anti-CLβ2GPI Ab (U/mL)	2.1 (<3.5)
Lupus anticoagulants	2.59 (<1.2)
HBV Ag	−
HCV Ab	+
HTLV-1 Ab	+
Electrophoresis
Serum M-protein	−
Urine M-protein	−
Test for hemolysis
Direct Coombs test	+
Direct antiglobulin test
IgG	3+
Complements	3+
Indirect Coombs test	+
Donath–Landsteiner test	−
Urinalysis
Protein	±
Occult blood	+

APTT, activated partial thromboplastin time; FDP, fibrin-fibrinogen degradation product; AST, aspartate aminotransferase; ALT, alanine aminotransferase; LD, lactate dehydrogenase; ALP, alkaline phosphatase; γ-GTP, γ-glutamyl transpeptidase; Na, sodium; K, potassium; Cl, chloride; Ca, calcium; Fe, iron; UIBC, unsaturated iron-binding capacity; TIBC, total iron-binding capacity; TSH, thyroid-stimulating hormone; T4, thyroxine; sIL-2R, soluble interleukin-2 receptor; BNP, brain natriuretic peptide; CRP, C-reactive protein; Ig, immunoglobulin; C3, third component of complement; C4, fourth component of complement; Ab, antibodies; CLβ2GP1, cardiolipin β2 glycoprotein I; HBV, hepatitis B virus; HCV, hepatitis C virus; HTLV-1, human T-cell leukemia virus type-1. Numbers in parentheses indicate reference range.