|
Test | Result |
|
Bone marrow biopsy results |
Flow cytometry | No evidence of acute leukemia or increased blasts |
CD25 | Positive |
CD68 | Weakly positive |
CD117 | Positive |
CD3, CD5, CD10, CD20, CD34, MPO, TDT, cyclin D1, DBA-4A, BCL6 | Negative |
Ki67 | 5% |
Full-leukemia panel for translocation | Negative |
Karyotype | 46 XX |
Histology | 90% cellular bone marrow Diffuse population of medium-sized cells with round to kidney-shaped nuclei, and moderate to abundant cytoplasm with retraction, seen surrounding aggregates of small lymphocytes and admixed with increased eosinophils |
|
Blood test done while on midostaurin 2 weeks prior to presentation: |
CBC | Hb: 10.3 g/dL MCV: 103.7 fL WBCs: 4100/µL | Neutrophils: 70% Lymphocytes: 21% | Eosinophils: 4% Platelets: 117000/µL |
|
Blood test in the ED on presentation |
CBC | Hb: 7.8 g/dL MCV: 104.2 fL WBCs: 3500/µL | Neutrophils: 74% Lymphocytes: 15% | Eosinophils: 3% Platelets: 75000/µL |
CRP | 172 mg/dL |
ESR | 119 mm/h |
Procalcitonin | 0.45 ng/mL |
|
Urine studies in the ED on presentation |
Urine analysis | WBCs: numerous; RBCs: 2–4 Leukocyte esterase: negative; nitrites: negative; squamous epithelia: present casts: negative; crystals: negative; bacteria: negative |
Urine culture | Negative |
|
Infectious workup during admission |
PCR (parvovirus, adenovirus, chlamydia, gonorrhea, TB) | Not detected |
Bacterial culture | Negative |
Fungal culture | Negative |
AFB smear | Negative |
16S RNA | Negative |
Synovial fluid analysis | RBCs: 5610/µL; WBCs: 1230/µL; N: 77%; L: 12%; Mono: 8%; Eo: 3% |
Synovial fluid polarizing microscopy | No crystals seen Many RBCs and 10–15 WBCs |
|