Significance of Estrogen/Progesterone Receptor Expression in Metaplastic Breast Carcinoma

Table 4

Association of clinicopathological parameters with different combinations of estrogen and progesterone receptor expression.

Clinicopathological parameters	Values				p-Value
	ER/PR expression
	ER+, PR+	ER+, PR−	ER−, PR+	ER−, PR−
Age (years), Mean ± SD	52.75 ± 10.60	56.00 ± 16.54	43.00 ± 0.00	51.70 ± 11.73	0.239
Age group
≤35 years, n (%)	0 (0)	2 (11.1)	0 (0)	14 (14.9)	0.045
36–50 years, n (%)	10 (41.7)	4 (22.2)	4 (100)	34 (36.2)
>50 years, n (%)	14 (58.3)	12 (66.7)	0 (0)	46 (48.9)
Follow-up duration (months), Mean ± SD	4.41 ± 2.06	4.44 ± 1.68	5.50 ± 1.73	3.95 ± 1.86	0.268
Tumor laterality
Right breast, n (%)	12 (50)	8 (44.4)	0 (0)	58 (61.7)	0.050
Left breast, n (%)	12 (50)	10 (55.6)	4 (100)	36 (38.3)
Tumor size (cm), n = 92	3.00 ± 1.26	7.83 ± 3.35	NA	6.62 ± 3.43	<0.001
Tumor (T) stage, n = 92
T1, n (%)	4 (22.2)	0 (0)	0 (0)	8 (11.8)	<0.001
T2, n (%)	14 (77.8)	2 (33.3)	0 (0)	18 (26.5)
T3, n (%)	0 (0)	4 (66.7)	0 (0)	42 (61.8)
Tumor grade
Grade 2, n (%)	8 (33.3)	8 (44.4)	4 (100)	14 (14.9)	<0.001
Grade 3, n (%)	16 (66.7)	10 (55.6)	0 (0)	80 (85.1)
Squamous differentiation
Present, n (%)	14 (58.3)	12 (66.7)	4 (100)	66 (70.2)	0.426
Absent, n (%)	10 (41.7)	6 (33.3)	0 (0)	28 (29.8)
Chondroid differentiation
Present, n (%)	4 (16.7)	0 (0)	0 (0)	4 (4.3)	0.100
Absent, n (%)	20 (83.3)	18 (100)	4 (100)	90 (95.7)
Spindle cell differentiation
Present, n (%)	0 (0)	4 (22.2)	0 (0)	12 (12.8)	0.102
Absent, n (%)	24 (100)	14 (77.8)	4 (100)	82 (87.2)
Nodal (N) stage, n = 92, n (%)
N0, n (%)	14 (77.8)	0 (0)	0 (0)	38 (55.9)	<0.001
N1, n (%)	4 (22.2)	0 (0)	0 (0)	14 (20.6)
N2, n (%)	0 (0)	6 (100)	0 (0)	4 (5.9)
N3, n (%)	0 (0)	0 (0)	0 (0)	12 (17.6)
Recurrence, n (%)
Yes, n (%)	4 (16.7)	12 (66.7)	4 (100)	24 (25.5)	<0.0001
No, n (%)	20 (83.3)	6 (33.3)	0 (0)	70 (74.5)
Survival status, n (%)
Alive, n (%)	24 (100)	10 (55.6)	0 (0)	66 (70.2)	<0.001
Expired, n (%)	0 (0)	8 (44.4)	4 (100)	28 (29.8)

One-way ANOVA was applied, Chi-square/Fisher’s exact test was applied, p-value significant as <0.05. ER: estrogen receptor; PR: progesterone receptor; SD: standard deviation; T: tumor; N: nodal.