Research Article
Developing Clinical Phenotype Data Collection Standards for Research in Africa
Table 1
Overview of structure of data collection toolkits developed by H3Africa.
| Toolkit | Protocols |
| Core phenotypes | Demographics+ | Smoking exposure± | Drug use# | Dyslipidemia# | CVD∗ Core# | Anthropometrics+ | Smoking status# | Medication log+ | Cancer core+ | HIV core# | Blood pressure# | Alcohol exposure− | Diabetes history+ | Kidney disease core# | Infectious disease core+ | Urine results# | Alcohol use# | Asthma− | Stroke history core# | |
| Environmental factors | Household characteristics+ | Sanitation+ | Occupational exposures# | Personal care products# | | Water resource+ | Occupational history# | Air contaminants# | | |
| Lifestyle factors | Physical activity# | Dietary supplements# | Diet+ | Caffeine intake# | Sleep habits# |
| General medical history | Vaccinations# | Current pregnancy status± | Last pregnancy outcome± | | | Allergies+ | Pregnancy history± | Medical history± | | |
| Family history | Family composition± | Family history± | Family history of traumatic life events± | | |
| Cardiovascular disease | Angina# | Congestive heart failure# | Cardiac blood flow measurements± | | | Heart attack# | Thyroid disease# | Cardiovascular disease blood biomarkers± | | |
| Stroke | Stroke characterisation± | Prestroke risk reduction strategies± | Poststroke risk reduction strategies± | | |
| Cancer | Cancer prognosis and treatment+ | Cancer screenings# | Cancer family history± | | |
| Kidney disease | Kidney treatment status# | Kidney function assay# | Complete blood cell count | | |
| Rare and developmental disorders | Biological parents and grandparents± | Developmental milestones± | Developmental disorders± | Rare disorders± | | Birth history± | Neurodevelopmental assessment± | Epilepsy screener# | | |
| Infectious diseases | Malaria exposure and treatment± | Trypanosomiasis signs and symptoms+ | TB signs and symptoms± | HIV treatment± | Liver function assay# | Malaria testing# | TB history+ | Sexual behaviour# | CD4 count and percentage# | HIV signs and symptoms+ | Malaria signs and symptoms+ | TB testing# | HIV exposure± | Quantitative viral load# | STDs± | Trypanosomiasis testing# | Current TB+ | HIV detection test# | Complete blood cell count# | STD signs and symptoms+ |
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CVD: cardiovascular disease; HIV: human immunodeficiency virus; TB: tuberculosis; STD: sexually transmitted disease; +adapted protocols; ±novel protocols; #existing protocols. |