Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria

Figure 3

(a) Biofilm inhibition effect caused by test compounds against P. aeruginosa. Concentrations of RABYL-TOL and P-Z (1/2 MIC: 0.9750 µg/mL, 1/4 MIC: 0.4875 µg/mL, 1/8 MIC: 0.2438 µg/mL, and 1/16 MIC: 0.1219 µg/mL). P-MEOXY [1/2 MIC: 1.9500 µg/mL, 1/4 MIC: 0.9750 µg/mL, 1/8 MIC: 0.4875 µg/mL, and 1/16 MIC: 0.2438 µg/mL]. 2ET-TOL [1/2 MIC: 0.00625 µg/mL, 1/4 MIC: 0.003125 µg/mL, 1/8 MIC: 0.0015625 µg/mL, and 1/16 MIC: 0.00078125 µg/mL]. (b) Biofilm inhibition effect caused by test compounds against Staphylococcus aureus. Concentrations of P-MEOXY and P-Z (1/2 MIC: 250 µg/mL, 1/4 MIC: 125 µg/mL, 1/8 MIC: 62.5 µg/mL, and 1/16 MIC: 31.25 µg/mL). RABYL-TOL (1/2 MIC: 125 µg/mL, 1/4 MIC: 62.5 µg/mL, 1/8 MIC: 31.25 µg/mL, and 1/16 MIC: 15.625 µg/mL). 2ET-TOL (1/2 MIC: 15.625 µg/mL, 1/4 MIC: 7.8125 µg/mL, 1/8 MIC: 3.90625 µg/mL, and 1/16 MIC: 1.953125 µg/mL).

(a)

(b)