Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria

<table class="table-group" id="tab2"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left" rowspan="2">Compounds</td><td class="align_center" colspan="2">FICI</td></tr><tr class="thead"><td class="align_center"><i>P. aeruginosa</i></td><td class="align_center"><i>S. aureus</i></td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">Amoxicillin + P-MEOXY (1)</td><td class="align_center">1 (NI)</td><td class="align_center">—</td></tr><tr><td class="align_left">Amoxicillin + 2ET-TOL (2)</td><td class="align_center">0.75 (NI)</td><td class="align_center">6 (AT)</td></tr><tr><td class="align_left">Amoxicillin + RABYL-TOL (4)</td><td class="align_center">0.25 (S)</td><td class="align_center">2.125 (NI)</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr><tr class="table-fn"><td><div>The synergistic effect is expressed as the fractional inhibition concentration index (FICI), calculated from the MIC of the various compound/antimicrobial combinations. The FIC index interactions were defined as follows: FICI ≤0.5, (S) synergy &gt;0.5 to ≤4.0 (NI) no interaction, and &gt;4.0, (AT) antagonistic.<br/></div></td></tr></table>

<div>Fractional Inhibitory Concentration Indices of the combination of the compounds and Amoxicillin.</div>

Heteroatom Chemistry

tab2

Table 2

Table 2: Synthesized Phosphonium Compounds Demonstrate Resistant Modulatory and Antibiofilm Formation Activities against Some Pathogenic Bacteria 