Novel Thioethers of Dihydroartemisinin Exhibiting Their Biological Activities

Table 1

Nitric oxide inhibitory activity of test compounds on RAW 264.7 macrophages.

Sample’s name	Test concentration (µg/mL)	NO inhibition (%)	Cell survival (%)	NO half-maximal inhibitory concentration (IC50, µM)
(+) control	0.39	62.46 ± 1.27	98.22 ± 1.56	0.87 ± 0.07
5a	2.5	67.24 ± 1.78	96.91 ± 1.71	4.30 ± 0.18
5b	1.25	67.68 ± 0.81	93.01 ± 2.14	2.64 ± 0.09
5c	5	69.77 ± 0.52	96.70 ± 1.05	8.39 ± 0.21
5d	2.5	77.93 ± 0.88	93.48 ± 2.38	3.54 ± 0.11
5e	1.25	59.74 ± 3.04	96.52 ± 0.93	2.56 ± 0.07
5f	2.5	77.22 ± 1.30	94.11 ± 1.89	3.35 ± 0.13
5g1	5	75.43 ± 1.57	97.50 ± 0.47	7.88 ± 0.05
5h	1.25	67.93 ± 2.25	93.57 ± 1.56	1.48 ± 0.10
5i	1.25	0	96.87 ± 1.72	—
5k	1.25	65.84 ± 0.92	97.41 ± 2.61	2.06 ± 0.12

Data represent the mean ± standard deviation of three independent wells. Positive control: dexamethasone 1 mM (Merck, Germany).