Research Article
Novel Thioethers of Dihydroartemisinin Exhibiting Their Biological Activities
Table 1
Nitric oxide inhibitory activity of test compounds on RAW 264.7 macrophages.
| Sample’s name | Test concentration (µg/mL) | NO inhibition (%) | Cell survival (%) | NO half-maximal inhibitory concentration (IC50, µM) |
| (+) control | 0.39 | 62.46 ± 1.27 | 98.22 ± 1.56 | 0.87 ± 0.07 | 5a | 2.5 | 67.24 ± 1.78 | 96.91 ± 1.71 | 4.30 ± 0.18 | 5b | 1.25 | 67.68 ± 0.81 | 93.01 ± 2.14 | 2.64 ± 0.09 | 5c | 5 | 69.77 ± 0.52 | 96.70 ± 1.05 | 8.39 ± 0.21 | 5d | 2.5 | 77.93 ± 0.88 | 93.48 ± 2.38 | 3.54 ± 0.11 | 5e | 1.25 | 59.74 ± 3.04 | 96.52 ± 0.93 | 2.56 ± 0.07 | 5f | 2.5 | 77.22 ± 1.30 | 94.11 ± 1.89 | 3.35 ± 0.13 | 5g1 | 5 | 75.43 ± 1.57 | 97.50 ± 0.47 | 7.88 ± 0.05 | 5h | 1.25 | 67.93 ± 2.25 | 93.57 ± 1.56 | 1.48 ± 0.10 | 5i | 1.25 | 0 | 96.87 ± 1.72 | — | 5k | 1.25 | 65.84 ± 0.92 | 97.41 ± 2.61 | 2.06 ± 0.12 |
|
|
Data represent the mean ± standard deviation of three independent wells. Positive control: dexamethasone 1 mM (Merck, Germany). |