Novel Thioethers of Dihydroartemisinin Exhibiting Their Biological Activities

Table 3

In vitro cytotoxic activity of the synthesized conjugates.

No.	Compounds	IC50 (μM)
		Hep-G2	LU-1
1	5a	10.76 ± 0.13	41.73 ± 0.59
2	5b	11.33 ± 0.65	41.90 ± 0.25
3	5c	—	—
4	5d	5.75 ± 0.51	21.90 ± 0.14
5	5e	5.70 ± 0.33	20.86 ± 0.09
6	5f	6.34 ± 0.10	22.36 ± 0,24
7	5g1	—	—
8	5h	2.73 ± 0.06	13.06 ± 0,15
9	5i	11.09 ± 0.32	33.74 ± 0,51
10	5k1	10.43 ± 0.30	38.60 ± 0,29
11	DHA	21.00 ± 0.91	79,63 ± 0.68
12	Ellipticine	1.06 ± 0,05	1.38 ± 0,12

Ellipticine (Merck, Germany) was employed as a positive control.