RuX: A Novel, Flexible, and Sensitive Mifepristone-Induced Transcriptional Regulation System

Figure 1

The modular structure of the rat glucocorticoid receptor (rGR). Scheme of the three major functional domains of the rGR. P denotes the potentiator domain, DBD is the DNA binding domain, and HBD is the hormone-binding domain. The operational borders of the domains are given by their amino acid positions below the rGR map (red numbers). Below: localization and quantitative estimation of the known major activities (listed at the left) of the rGR. The number and the pattern of the lozenges indicate the relative importance of the protein segment for a specific function (empty: minor; filled: primary). Abbreviations: bdg: binding; loc: localization.