The Effect of Differentiation of Human Dental Pulp Stem Cells to Glial Cells on the Sensory Nerves of the Dental Pulp

Figure 6

Candidate mRNA selection from RNA-seq analysis: (a) bar graph shows the gene expression in the 6-day and 10-day induced and noninduced groups; (b) the Venn diagrams illustrate 2,257 genes that were significantly upregulated between induced 6 days and noninduced conditions; 902 genes were downregulated between days 6 and 10 of induction (log2FC > 2; Q value < 0.001); (c) STRING database and cytoscape show the interaction of 154 genes, including one key gene; (d) Kyoto encyclopedia of genes and genomes pathway analysis of associated mRNAs of 154 genes (bubble chart and bar chart on the left and right sides, respectively); and (e) gene ontology enrichment analysis of associated mRNAs of 154 key genes (from left to right—cellular component, molecular function, and biological process). Induced 6 days means supernatant on the sixth day of differentiation of Schwann-like cells derived from dental pulp stem cells (SC-DPSCs); induced 10 days means supernatant on the tenth day of differentiation of SC-DPSCs.

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