Identification of ZIC2 as a Potential Biomarker Linked with the Clinical Progression and Immune Infiltration of Oral Cancer: A Multicenter Study

Figure 1

Expression pattern of ZIC2 in oral cancer samples from in-house tissue microarray: (a) immunohistochemistry pictures representing high protein level of ZIC2 in oral cancer tissues (×100); (b) immunohistochemistry pictures representing high protein level of ZIC2 in oral cancer tissues (×200); (c) immunohistochemistry pictures representing high protein level of ZIC2 in oral cancer tissues (×400); (d) immunohistochemistry pictures representing low protein level of ZIC2 in noncancer oral tissues (×100); (e) immunohistochemistry pictures representing low protein level of ZIC2 in noncancer oral tissues (×200); (f) immunohistochemistry pictures representing low protein level of ZIC2 in noncancer oral tissues (×400); (g) box plot showing the comparison of ZIC2 expression between oral and noncancer oral tissues; (h) ROC curves of the discerning ability of ZIC2 expression for oral cancer tissues; (i) box plot showing the comparison of ZIC2 expression between oral cancer patients with or without lymph node metastasis; (j) ROC curves of the discerning ability of ZIC2 expression for oral cancer patients with lymph node metastasis.