Pathology of Hepatocellular Carcinoma and Tumor-Bearing Liver Tissue in Association with hTERT Promoter Mutation

Table 1

hTERT promoter mutation in hepatocellular carcinoma (HCC): association with causative clinical disease.

	Causative disease		hTERT mutation absolute numbers and %	Wildtype hTERT absolute numbers and %	Comparative test
1	Without causative disease	Cirrhosis	15 (68.2)	7
2	With causative disease	Cirrhosis	56 (78.9)	15	2 vs. 1	0.30
3	ALD	Cirrhosis	27 (87.1)	4	3 vs. 1	0.09
4	Hepatitis B	Cirrhosis	8 (57.1)	6	4 vs. 1	0.50
5	Hepatitis C	Cirrhosis	4	13	5 vs. 1	0.57
6	Hepatitis B and C	Cirrhosis	0	1
7	ALD and hepatitis B	Cirrhosis	1	2
8	ALD and hepatitis C	Cirrhosis	0	2
9	ALD in other combinations	Cirrhosis	0	2
10	Other	Cirrhosis	0	1
	Total	Cirrhosis	71	22
11	Without primary disease	Non-cirrhosis	18 (47.7)	20	11 vs. 1	0.11
12	With primary disease	Non-cirrhosis	12 (41.4)	17	12 vs. 2	<0.00
13	ALD	Non-cirrhosis	7 (40.0)	6
14	Hepatitis B	Non-cirrhosis	3 (40.0)	2
15	Hepatitis C	Non-cirrhosis	3 (50.0)	3
16	Hepatitis B and C	Non-cirrhosis	0	0
17	ALD and hepatitis B	Non-cirrhosis	1	0
18	ALD and hepatitis C	Non-cirrhosis	1	0
19	ALD and hepatitis B and C	Non-cirrhosis	1	0
20	Other	Non-cirrhosis	1 (50.0)	1
21	Total	Non-cirrhosis	30	37

ALD: alcoholic liver disease. Chi-square test. Fisher’s exact test.