Pathology of Hepatocellular Carcinoma and Tumor-Bearing Liver Tissue in Association with hTERT Promoter Mutation
Table 3
hTERT promoter mutation in hepatocellular carcinoma (HCC) in noncirrhotic liver: correlation of mutation frequency with minor histological parenchymal damage (inflammation, fibrosis, and steatosis).
Pathological tissue changes
Number of cases with hTERT promoter mutation/number of cases with hTERT wildtype
hTERT promoter mutation %
Comparative test
Cirrhosis
71/22
76.3
Non-cirrhosis, all cases
30/37
44.8
2 vs. 1
0.00
Non-cirrhosis -4; ;
14/14
50
Non-cirrhosis ;;
16/23
41
4 vs. 3
0.47
Non-cirrhosis ;;
3/7
30
5 vs. 3
0.46
F: stage of fibrosis [8], with a maximum of 6 points possible; mHAI: modified histological activity index [8], with a maximum of 18 points possible; S: steatosis (in %). Chi-square test.
