Full-Length Genome Sequencing and Analysis of Hepatitis B Viruses Isolated from Iraqi Patients

Table 4

Mutations and amino acid substitutions in the X region.

Region	Mutation	aa substitution	Mutation possible effect	Reference
X; (1374–1838 nt)	T1449C	C26R	CHB, LC	[27]
	T1464C	S31P	CHB, LC	[27]
	T1470C	S33P	U	Current study
	A1479T	T36S	LC	[28]
	T1494A	S41T	U	Current study
	C1509T	P46S	CHB, LC	[27]
	A1634C	Q87H	U	Current study
	A1637C	I88F	U	Current study
	C1653T	H94Y	CHB, HCC	[27]
	C1678T	A102V	CHB, LC	[27]
	A1752C	I127L	CHB, LC	[27]
	A1762T	K130M	CHB, LC	[27]
	T1768A	F132Y	LC	[28]

Bold font mutation: indicated known referenced mutation, aa: amino acid, CHB: chronic hepatitis, HCC: hepatocellular carcinoma, LC: liver cirrhosis, U: uncharacterized effect.