Research Article
Full-Length Genome Sequencing and Analysis of Hepatitis B Viruses Isolated from Iraqi Patients
Table 5
Mutations and amino acid substitutions in the PreS1-S region.
| Region | Mutation | aa substitution | Mutation possible effect | Reference |
| PreS1 (2848–3171 nt) | A2965C | T40P | U | Current study | G3082A | A79T | U | Current study | T3100G | S85A | U | Current study | A3154G | N103D | U | Current study |
| PreS2 (3172−154 nt) | T96C | L36P | U | Current study | C105T | A39V | HCC | [29] | C111A | P41H | U | Current study | T113A | L43I | U | Current study | A141G | D51G | U | Current study |
| S (155–835 nt) | A162G | N3S | U | [30] | G183A | G10R | U | Current study | T213C | F20S | U | Current study | G225A | R24K | HCC | [31] | C242A | Q30K | U | Current study | T279G | L42R | U | Current study | T528C | M125T | IE | [32] | A533C | T127P | U | Current study | T678C | L175S | U | Current study | C732T | S193L | U | Current study | C762G | P203R | U | Current study |
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Bold font mutation: indicated known referenced mutation, aa: amino acid, HCC: hepatocellular carcinoma, IE: immune escape, U: uncharacterized effect.
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